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The prodrug approach: A successful tool for improving drug solubility
(2016-01-01)
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their ...
Development and characterization of a biocompatible soybean oil-based microemulsion for the delivery of poorly water-soluble drugs
(Wiley-Blackwell, 2015)
The aim of this work was the development and characterization of a biocompatible microemulsion (ME) containing soybean oil (O), phosphatidylcholine/sodium oleate/Eumulgin®HRE40 as the surfactant mixture (S) and water or ...
Nanonization techniques to overcome poor water-solubility with drugs
(Universidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ALIMENTOSUFMG, 2020)
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility
(2016-03-01)
Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly ...
Drug-loaded lipid-core micelles in mucoadhesive films as a novel dosage form for buccal administration of poorly water-soluble and biological drugs
(MDPI, 2020)
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive ...
Nanotechnology-based drug delivery systems for treatment of hyperproliferative skin diseases - a review
(2013-04-12)
The chronic hyperproliferative diseases (CHD) include cancer, precancerous lesions and diseases of unknown etiology such as psoriasis. Various drugs have been used in the treatment of CHD, such as antiproliferative and ...
Nanotechnology-based drug delivery systems for treatment of hyperproliferative skin diseases - a review
(2013-04-12)
The chronic hyperproliferative diseases (CHD) include cancer, precancerous lesions and diseases of unknown etiology such as psoriasis. Various drugs have been used in the treatment of CHD, such as antiproliferative and ...
Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin
(MDPI, 2023-01)
The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility ...